Wednesday, August 19, 2015

New Compounds Could Reduce Alcoholics’ Impulse to Drink

BOSTON, Aug. 19, 2015 — Alcoholism inflicts a heavy physical, emotional and financial toll on individuals and society. Now new discoveries and promising animal studies are offering a glimmer of hope that a new class of drugs could treat the disease without many of the unwanted side effects caused by current therapies.

Researchers are presenting the results of their work today at the 250th National Meeting & Exposition of the American Chemical Society (ACS), the world’s largest scientific society. The meeting features more than 9,000 presentations on a wide range of science topics and is being held here through Thursday.

“Alcoholism is a major problem in the U.S.,” V. V. N. Phani Babu Tiruveedhula says. “Alcohol abuse costs almost $220 billion to the U.S. economy every year. That’s a shocking number. We need a better treatment right now.” Tiruveedhula is a graduate student at the University of Wisconsin, Milwaukee.

The exact causes of alcoholism are not well understood, but the researchers explain that the urge to drink is related to the brain’s pleasure centers. Scientists have found that alcohol triggers the brain to release dopamine, the same neurochemical whose levels increase in response to pleasurable behavior like eating, sex or listening to music.

Some drugs currently available to treat alcoholism are aimed at dopamine. “They dampen out the dopamine system a little bit, so you don’t get so happy when you have an alcoholic beverage,” says James Cook, Ph.D., a chemist at the University of Wisconsin, Milwaukee, who advises Tiruveedhula. But these medications, derived from a class of compounds called opioid antagonists, cause depression in some patients, Cook notes. And they’re addictive themselves, which can lead to drug abuse. Valium is an example of another common drug used to treat alcoholism that is also addictive.

Looking for an alternative, Cook focused on molecules known to cause some of the same results as Valium and the opioid antagonists without the unwanted side effects. For almost two decades, Cook collaborated with the late Harry June, Ph.D., a psychopharmacologist at Howard University. They conducted laboratory tests to understand the effects of these new compounds and to discover which ones work best.

Now, Tiruveedhula has made several of these promising beta-carboline compounds that could represent the future of alcoholism treatment. Tiruveedhula simplified their manufacture from eight steps to just two, while increasing the yield tenfold and eliminating unwanted byproducts. Cook says these potential medications could be taken orally.

In tests using rats bred to crave alcohol, the scientists found that administering these compounds drastically diminished the rats’ drinking. What’s more, they observed very few of the side effects common to alcoholism treatment drugs, such as depression and losing the ability to experience pleasure. The drugs appeared to reduce anxiety in “alcoholic” rats, but not in control rats. Because this is different from what is seen with current drugs, the researchers think the result hints that the new compounds work much differently than opioid antagonists. As such, the beta-carbolines may also be less addictive.

“What excites me is the compounds are orally active, and they don’t cause depression like some drugs do,” says Cook.

The group is continuing to test the compounds in additional animal studies. Cook has patented several of the most promising compounds, and he is starting to explore possible partnerships with drug makers that could lead to medications.

If everything works out, Cook says, a drug could be ready for the market in five to six years.

The researchers acknowledge funding from the National Institute on Alcohol Abuse and Alcoholism.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 158,000 members, ACS is the world’s largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

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Saturday, August 15, 2015

Study Finds Lack of Ultimate Meaning in Life Associated with Alcohol Abuse, Drug Addiction and Other Mental Health Problems

Newswise, August 15, 2015 — One of the most commonly used treatment models in addiction is the 12-step model developed in the 1930s and rooted in spirituality. Yet, surprisingly, there is no clear understanding about how to nurture spirituality among people struggling with addictions.

In a unique study titled “Attachment Style, Spirituality, and Depressive
Symptoms Among Individuals in Substance Abuse Treatment,” published in the Journal of Social Service Research, Gail Horton, Ph.D., associate professor; Naelys Luna, Ph.D., associate professor, School of Social Work in the College for Design and Social Inquiry at Florida Atlantic University, and Tammy Malloy, LCSW, chief clinical officer, Behavioral Health of the Palm Beaches (BHOPB), demonstrate that the lack of ultimate meaning in life, an important dimension of spirituality, is associated with alcohol abuse and drug addiction, as well as other mental health problems including anxiety and depression. 

Although adult attachment styles and spirituality have been shown to be protective factors against depressive symptoms among individuals in treatment for substance use disorders, no studies to date have examined how these two factors together are related to depressive symptoms in this population.
Horton, Luna and Malloy looked at how adult attachment styles (secure vs. insecure) and two distinct spirituality dimensions (existential purpose/meaning in life and religious well-being or the perceived relationship with God) are associated with depressive symptoms.
Working in collaboration with BHOPB, a substance abuse treatment center in Palm Beach County, Horton, Luna and Malloy developed a research model that looks at how creativity, service and solitude can be used in addiction treatment to foster purpose and meaning in life. They found that encouraging people’s creative talents (painting, writing), giving them opportunities to serve others, and helping them to connect to core values and their true self through prayer and meditation helped them to discover ultimate purpose and meaning as part of their recovery process.
A key finding of their research shows that having an insecure attachment style appears to be a risk factor for developing depressive symptoms. Another significant finding shows that the existential-purpose and meaning-in-life dimension of spirituality seems to be the most important factor related to depressive symptoms in this sample population.
Horton and Luna note that although their research results suggest that practitioners could consider focusing on promoting improved interpersonal relationships for individuals with insecure attachment styles, they may want to place fostering purpose and meaning in life as a higher priority for treatment planning.
“Programs such as the 12-step model might want to take into consideration the relative importance of the two spiritual dimensions and put into place programmatic support for the development of purpose and meaning in life rather than only stressing the perceived closeness to God,” said Malloy.

Addiction is one of the most damaging health problems in the U.S. today and the World Health Organization (WHO) reports that by 2020, mental health and substance use disorders will be a major cause of disability worldwide surpassing physical illness. 

In 2009, an estimated 23.5 million Americans ages 12 and older required addiction treatment. The societal cost of substance abuse problems is approximately $511 billion.

“The cutting-edge research conducted by Drs. Horton and Luna and Ms. Malloy is extremely important because it sheds light on different ways to help individuals in treatment addiction,” said John R. Graham, Ph.D., professor and director of FAU’s School of Social Work. 

“This in turn not only helps the clients receiving treatment, but also improves how addiction professionals do their work - contributing to the health and well-being of the broader community.”

Florida Atlantic University
Florida Atlantic University, established in 1961, officially opened its doors in 1964 as the fifth public university in Florida. Today, the University, with an annual economic impact of $6.3 billion, serves more than 30,000 undergraduate and graduate students at sites throughout its six-county service region in southeast Florida. FAU’s world-class teaching and research faculty serves students through 10 colleges: the Dorothy F. Schmidt College of Arts and Letters, the College of Business, the College for Design and Social Inquiry, the College of Education, the College of Engineering and Computer Science, the Graduate College, the Harriet L. Wilkes Honors College, the Charles E. Schmidt College of Medicine, the Christine E. Lynn College of Nursing and the Charles E. Schmidt College of Science. FAU is ranked as a High Research Activity institution by the Carnegie Foundation for the Advancement of Teaching. The University is placing special focus on the rapid development of critical areas that form the basis of its strategic plan: Healthy aging, biotech, coastal and marine issues, neuroscience, regenerative medicine, informatics, lifespan and the environment. These areas provide opportunities for faculty and students to build upon FAU’s existing strengths in research and scholarship. For more information, visit
Behavioral Health of the Palm Beaches
Behavioral Health of the Palm Beaches (BHOPB) is a leading addiction care organization located in South Florida offering patients comprehensive treatment for chemical dependency and mental illness. Comprised of four specialty facilities (the Recovery Center for Men, the Recovery Center for Women, Seaside Palm Beach, and Mental Health Rehab of the Palm Beaches). BHOPB provides patients with individualized care programs that span the entire treatment process, from intervention services to medically supervised detoxification to customized inpatient rehab to aftercare. Since its inception in 1997, BHOPB has grown to be one of the top addiction care organizations in the country through an ever-expanding spectrum of therapies, world-renowned research department and industry-leading clinical staff. For more information visit